WebJun 13, 2024 · Camptothecin is an anticancer molecule which acts by targeting the human deoxyribonucleic acid topoisomerase I (Topo-I). It inhibits the enzyme by blocking the re-joining step of the cleavage reaction of Topo-I, which causes accumulation of a covalent reaction intermediate. WebCamptothecin is a potent anti-tumor drug that specifically targets DNA topoisomerase I by reversibly stabilizing a covalent enzyme-DNA intermediate (reviewed in Refs. 2 , 4 , 5 , 6 , 7 ). In the yeast Saccharomyces cerevisiae, DNA topoisomerase I has been shown to constitute the cellular target of the drug ( 8 , 9 , 10 , 11 , 12 , 13 , 14 ).
Topoisomerase I inhibitors: camptothecins and beyond …
WebJan 28, 2010 · This review summarizes the in vivo assessment—preliminary, preclinical, and clinical—of chemotherapeutics derived from camptothecin or a derivative. Camptothecin is a naturally occurring, pentacyclic quinoline alkaloid that possesses high cytotoxic activity in a variety of cell lines. Major limitations of the drug, including poor solubility and hydrolysis … WebUsed for centuries in traditional Chinese medicine, camptothecin was rediscovered in the 1950s during a search for compounds that could be used as a source for steroid … can step children marry
Induction of neuronal apoptosis by camptothecin, an inhibitor …
WebAug 1, 1996 · Camptothecin is an S-phase-specific anticancer agent that inhibits the activity of the enzyme DNA topoisomerase-I (topo-I). Irreversible DNA double-strand breaks are produced during DNA synthesis in the presence of camptothecin, suggesting that this agent should not be toxic to nondividing cells, such as neurons. WebYou’re taking chemotherapy medications such as camptothecin (Camptosar®), mechlorethamine (Mustargen®), doxorubicin (Adriamycin®, Rubex®), or … WebSAFETY DATA SHEET Creation Date 03-Dec-2010 Revision Date 25-Dec-2024 Revision Number 4 1. Identification Product Name (+)-Camptothecin Cat No. : AC276720000; AC276720010; AC276721000 CAS No 7689-03-4 Synonyms 4-Ethyl-4-hydroxy-1H-pyrano-ó3`,4`:6,7!indolizinoó1,2-b!quinoline-3,14(4H,12H)-dione Recommended Use Laboratory … can step files be edited in solidworks