Cutll1 cell

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August undefined, 2024

WebJun 29, 2024 · Srivastava et al. identified the E3 ubiquitin ligase UBR7 as a NOTCH1 transcriptional target in the T-ALL cell line CUTLL1 4.Analysis of the publicly available cancer cell line encyclopedia (CCLE ... WebCell Line Passport: SIDM00759. Cellosaurus RRID: CVCL_1511. Growth Pattern: Adherent. Disease Non-Small Cell Lung Cancer Disease Subtype Lung Adenocarcinoma Lineage. Lung. Lineage Subtype Non-Small Cell Lung Cancer. Lineage Sub-subtype Lung Adenocarcinoma. Primary/Metastasis ...

Selective targeting of MYC mRNA by stabilized antisense ...

WebOct 14, 2024 · CUTLL1, MM1.S, and HLF cells were treated with MYCASO (gymnotic) for 72 h (CUTLL1 and MM1.S) or 120 h (HLF). Values represent quadruplicate means ± SD. b Cell numbers over time with MYCASO treatment. WebCUTLL1 cells were cultured in media with γ-secretase inhibitor (1μM) for 3 days and then either harvested immediately (left panel) or washed and cultured in fresh media for 3h … kronos workforce login wrha

NCIH1975 DepMap Cell Line Summary

WebDec 22, 2024 · The molecular characteristics of sEV in T-ALL were initially explored in CUTLL1 cell line, a well-characterized human T-cell lymphoma cell line derived from a pleural effusion in a pediatric patient with T-ALL at relapse, with aberrant NOTCH1 activation and strongly sensitive to γ-secretase inhibitors [].CUTLL1 cells were lentivirally … WebCUTLL1 Cells are derived from human T-cell lymphoblastic leukemia (T-ALL) which expresses high levels of NOTCH1. NOTCH1 is an important target in cancer therapies in … map of northeastern oh

Cell-type-specific prediction of 3D chromatin organization enables …

CUTLL1, a novel human T-cell lymphoma cell line with …

WebJan 27, 2024 · To test the effect of UBR7 on oncogenicity of T-ALL cell lines, control or UBR7 shRNA–expressing CUTLL1 and Jurkat cells were grown in methylcellulose-based three-dimensional culture medium. Consistent with the cell proliferation defects, UBR7 loss resulted in significantly fewer (~10-fold) and smaller colonies as compared to control … Webresistance in T-ALL.9 CUTLL1 cells are highly NOTCH dependent and have previously been shown to be dexametha-sone resistant and thus represent a good model in which to screen compounds. We screened 9517 compounds that had been selected for lead-like properties in CUTLL1 cells in 384-well format.10,11 Starting from 3372615 compounds, … map of northeastern minnesotaWebJan 21, 2024 · CUTLL1 cells (10 million per group) were treated with 3 nM E7107 or vehicle for 15 min or 24 hours and labeled with 500 μM 4-thiouridine for 10 min. Cells were … map of north east england with towns

"WebCell information for CUTLL1. Find diseases associated with this biological target and compounds tested against it in bioassay experiments. " - Cutll1 cell

Cutll1 cell

Preclinical Analysis of the -Secretase Inhibitor PF-03084014 in ...

WebJul 30, 2024 · e Representative plots of cell-cycle distribution in CUTLL1 cells stably expressing Cas9 or sgGLI1 and maintained for 48 h in regular culture medium (10% FCS) or serum-free medium (0.5% BSA). WebGiven the central role of Notch in T-cell acute lymphoblastic leukemia oncogenesis, these data pave the way towards development of novel therapeutic strategies that target …

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WebAug 1, 2006 · mmunophenotypic characterization of CUTLL1 cell line. CUTLL1 cells were stained with the indicated antibodies and analysed by flow cytometry. High expression of … WebPubMed

WebCUTLL1 cells were cultured in media with γ-secretase inhibitor (1 μM, 3 d) and then either harvested immediately (left panel) or washed and cultured in fresh media for 3 h (right … WebCUTLL1 is a human T-cell lymphoblastic lymphoma cell line derived from a relapsed patient that harbors a t (7;9) (q34;q34) chromosomal translocation resulting in expression of a …

WebTraditional polyclonal and monoclonal antibodies are the product of normal B cell development and genetic recombination. ... Immunohistochemical analysis of paraffin-embedded CUTLL1 cell pellets, control (left) or … WebFunction [ edit] The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It regulates gene expression, morphogenesis, and differentiation …

WebApr 13, 2012 · PF-03084014 reverses glucocorticoid resistance in human T-ALL cells (A) Cell viability assays of glucocorticoid-resistant T-ALL cell lines (CUTLL1, KOPTK1, TALL1) treated with PF-03084014 (1µM) plus increasing concentrations of dexamethasone. Data are represented relative to treatment with PF-03084014 plus vehicle control.

WebCUTLL1 cells demonstrate high sensitivity togamma-secretase inhibitors, which act on the Notch pathway. CUTLL1 cells express markers of immature T- cells including CD3, … map of northeast columbia scWebGiven the central role of Notch in T-cell acute lymphoblastic leukemia oncogenesis, these data pave the way towards development of novel therapeutic strategies that target … map of northeastern iowaWebApr 30, 2015 · The CUTLL1 cell line generated in our laboratory has been previously described. 9 Mouse primary tumors were cultured in vitro with OP9 stromal cells in OPTIMEM-Glutamax medium supplemented with mouse IL7 (10 ng/mL), β-mercaptoethanol (55 μM), 10% fetal bovine serum, and 1% penicillin/streptomycin for 2 weeks and then … map of north eastern michiganWebJan 9, 2024 · The impact score difference between target cell type (CUTLL1 and Jurkat) and T cell are shown on the x axis, and the higher impact scores between the … map of northeastern mnWebJan 9, 2024 · The impact score difference between target cell type (CUTLL1 and Jurkat) and T cell are shown on the x axis, and the higher impact scores between the corresponding cell type and the T cells are ... map of northeastern ohio citiesWebDec 22, 2024 · CUTLL1 and Jurkat cell lines transduced with these reporter constructs were cultured in either complete medium or medium lacking valine or tryptophan for 8 h with or without cycloheximide (CHX). map of northeastern oklahomaWebNov 4, 2014 · As in murine T-ALL cells, 3C assays showed that the human NDME interacted with the Myc promoter in CUTLL1 cells (Fig. 4B) and that this interaction was unaffected by short-term Notch inhibition . To confirm that the putative human NDME is a Notch-responsive element, luciferase reporter gene constructs containing a minimal … map of northeastern ohio