WebbAug 2024 - Nov 20244 years 4 months. Helsinki Area, Finland. • Coordinator of the TEHO (2024-2024) and Cancer IO projects (2024-2024), both Business Finland funded large public-private projects focusing on adaptive clinical trial design and immuno-oncology. • Created an international network of >100 KOLs across >10 countries and across all ... WebbThe SHANK gene family consists of three members (SHANK1, SHANK2, and SHANK3), which encode scaffolding proteins required for the proper formation and function of neuronal synapses. Although SHANK2 and SHANK3 mutations have been implicated in ASD and intellectual disability, the involvement of SHANK1 is unknown.
SHANK1 Deletions in Males with Autism Spectrum Disorder
Webb近日,复旦大学附属妇产科医院王红艳教授团队与复旦大学生命科学学院公晓红副教授等在 Molecular Psychiatry 期刊发表了题为:A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling 的研究论文。 该研究通过遗传改造的小鼠模型解析病源 … Webbmice, mutations in the genes encoding SHANK fam ily proteins (SHANK1, SHANK2 and SHANK3) often result in marked behavioural phenotypes. These include an increase in repetitive routines, altered social behav iour and anxietylike phenotypes, seemingly similar to those described in some human neuropsychiatric disorders9. it job canberra
Molecular Psychiatry:复旦大学王红艳/公晓红合作揭示自闭症核 …
WebbA recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling Article Full-text available Jul... Webb6 juli 2015 · Shank1-mutant mice were first generated in 2008 (Hung et al. 2008) characterized by a deletion of exon 14–15 lacking the PDZ domain and the all Shank1 splice variant, Shank1 (14–15). Recently, two Shank2-mutant mice were generated in two different laboratories; an exons 6–7 deleted mouse, Shank2 (6–7) (Won et al. Webb11 apr. 2024 · Conspicuously, RapP of B. subtilis NCIB 3610 shows an asparagine-to-threonine mutation at position 236 that is not present in the corresponding rapP alleles of other Bacillus strains. Omer Bendori et al. ( 2015 ) showed that this single amino acid substitution is responsible for the observed resistance of RapP to inhibition by PhrP, and … it job consultancy in ameerpet